Hello Bio, a leading innovator in life sciences is proud to announce it has been granted a license from the Oncode Institute and Universiteit Leiden to commercialise and release a range of novel adenosine receptor probes, making them available for the first time to life science researchers worldwide.
Adenosine receptors (A1, A2A, A2B and A3) are GPCRs implicated in physiological and pathophysiological conditions such as cancer, immune and inflammatory conditions, and cardiac-ischaemic disease.
The Oncode Institute and Universiteit Leiden have developed these adenosine receptor compounds and the cutting-edge range is composed of affinity-based probes (AfBP) and covalent binding ligands which will offer researchers new tools to advance the understanding of adenosine receptors. These include, LUF7909, which is a novel adenosine A1 receptor affinity-based probe which is suitable for click conjugation and use in applications such as confocal microscopy, SDS-PAGE and chemical proteomics profiling applications.
Other compounds include the novel, covalent Affinity-based probe LUF7487 and covalent ligands LUF7746, LUF7745, LUF7982 and LUF7602
Steve Roome PhD, Managing Director and Founder of Hello Bio, says: “We are thrilled to have been granted a licence from Oncode Institute and Universiteit Leiden to introduce this new range of adenosine probes to the research community. This range reflects our ongoing commitment to provide researchers with new tools to help support their research. We believe these probes will open new possibilities in the study of adenosine receptors and contribute to an improved understanding of their role in various biological processes.
These new compounds join Hello Bio’s unique range of adenosine receptor ligands which also include CA200634 CellAura fluorescent adenosine antagonist [XAC], CA200623 CellAura fluorescent adenosine agonist [NECA], A2A receptor antagonist: ZM241385, and A2A receptor agonist CGS 21680. We hope that these novel adenosine compounds will contribute to further pushing this exciting field of research forwards.”
Laura Heitman PhD, Professor of Molecular Pharmacology at Leiden Academic Centre for Drug Research and Oncode Investigator, adds: “The Oncode Institute Business Development team really helped me to identify partners potentially interested in the probes that we develop in Leiden. With their help, we were able to formalize our collaboration with Hello Bio and make our probes available to the field.”
More information on these probes can be found here:
- LUF7909 (HB4786): https://hellobio.com/luf7909.html
- LUF7487 (HB9585): https://hellobio.com/luf7487.html
- LUF7746 (HB6921): https://hellobio.com/luf7746.html
- LUF7745 (HB8439): https://hellobio.com/luf7445.html
- LUF7982 (HB9905): https://hellobio.com/luf7982.html
- LUF7602 (HB7286: https://hellobio.com/luf7602.html