In my lab, we investigate how cellular metabolism is not a bystander but a key regulator of fundamental cellular processes. Using cutting-edge imaging techniques alongside conventional tools, we visualize the dynamic metabolic shifts as they happen, across different cell types and within different cellular compartments. This approach allows us to gain deep understanding of how metabolites shape cell behaviour, influencing their state, fate, and function.
Metabolic Control of Cell Signalling and Epigenetics
We study how metabolic shifts, including those influenced by diet, affect tissue balance, cancer progression, and chemotherapy response. By understanding these connections, we aim to reveal new ways to regulate cell fate in cancerous tissues.
Mitochondrial Metabolism and Chromosomal Stability
Our recent findings show that metabolism during cell division not only fuels the process by producing energy but supports accurate chromosome segregation. Given that cancer cells have abnormal metabolism, we investigate how these disruptions contribute to chromosomal instability, a main driver of tumour progression and malignancy.
