Our Focus
We have established organotypic ex vivo culture systems (organoids) from multiple human and murine epithelial (diseased) organs. Organoids, mini-organs in a dish, allow all laboratory methods that are applied to cell lines, such as transfection, infection with recombinant viruses, imaging, in vitro throughput drug-screening, CRISPR-CAS9 modification, etc.
We aim to combine these technologies and thereby exploit the possibilities of the usage of (genetically modified) organoids in fundamental research, regenerative medicine, gene therapy or treating cancer (e.g. drug screenings and the testing of patient-specific drug treatments (personalized medicine).
Moreover, we are generating more complex organoid (disease) models that combine cancer cells with immune cells, defined stromal cells and/or microbes. This will allow us to model more closely -yet in a fully controlled way- the tumour environment and, for instance, the effects of immune modulators on cancers.
About Hans Clevers
Hans Clevers
Elected Memberships
1999 Member European Molecular Biology Organisation (EMBO)
2000 Member of the Royal Netherlands Academy of Sciences (KNAW)
2009 Member of the Academia Europaea
2012 Member of the American Academy of Arts and Sciences
2012 Member of the ‘Koninklijke Hollandsche Maatschappij der Wetenschappen’ (Royal Netherlands Society of Sciences and Humanities)
2014 International member of the National Academy of Sciences of the USA
2016 Member of the Academie des Sciences de I'Institut de France
2017 Member of the Orden Pour le Mérite für Wissenschaften und Künste, Germany
2019 Member of the New York Academy of Sciences, New York
2019 Foreign Member of the Royal Society of London
2019 Honorary Fellowship of the Royal Society of Edinburgh, Scotland’s National Academy of Science and Letters
Awards
2022: Ammodo Science Award
2022: Taobuk Da Vinci Award
2021: Pezcoller Foundation-AACR International Award
2019: Citation Laureate, Clarivate/Web of Science Group
2019: Keio Medical Science Prize, Tokyo, Japan
2018: Academia Europaea Erasmus Medal, Barcelona, Spain
2017: Großes Verdienstkreuz mit Stern, Germany
2017: Princess Takamatsu Award of Merit, Tokyo
2016: The Ilse & Helmut Wachter award, Hamburg, Germany
2016: Swammerdam medaille (Amsterdam)
2016: The Körber European Science Prize, Germany
2016: Kazemi Award for Research Excellence in Bio-Medicine
2016: the Academy Professor Prize of the Royal Netherlands Academy
2015: ISSCR-McEwen Award for Innovation
2014: National Icon of the Netherlands
2014: Struyvenberg European Society for Clinical Investigation (ESCI) medal
2014: Fellow of the AACR Academy
2014: TEFAF Oncology Chair 2014, Maastricht
2014: Massachusetts General Hospital Award in Cancer Research
2013: The Breakthrough Prize in Life Sciences
2012: Knight in the Order of the Nederlands' Lion
2012: The Heineken Prize for Medicine
2012: William Beaumont prize of the American Gastroenterology Association
2012: Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize, Paris
2011: Kolff prize, Amsterdam
2011: The Ernst Jung Medical Award, Germany
2010: The United European Gastroenterology Federation (UEGF) Research Prize
2009: The Queen Wilhelmina Dutch Cancer Society Award, Amsterdam
2008: Meyenburg Cancer Research Award, Germany
2008: Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam)
2006: Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research, Jerusalem
2005: Katharine Berkan Judd Award, New York
2005: the French honor of “Chevalier de la Legion d'Honneur”
2005: the Science and Society Prize, Amsterdam
2004: Louis-Jeantet Prize for Medicine, Geneva, Switzerland
2001: Spinoza Award of the Netherlands Reserach Council (NWO)
2001: Award from the European Society for Clinical Investigation
2000: Catharijne-prize for medical research
Key Publications
Barker, N., Van Es, J. H., Kuipers, J., Kujala, P., Van Den Born, M., Cozijnsen, M., ... & Clevers, H. (2007). Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature, 449(7165), 1003.
Drost, J., Van Jaarsveld, R. H., Ponsioen, B., Zimberlin, C., Van Boxtel, R., Buijs, A., ... & Clevers, H. (2015). Sequential cancer mutations in cultured human intestinal stem cells. Nature, 521(7550), 43.
Huch, M., Gehart, H., Van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M. M., ... & Clevers, H. (2015). Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell, 160(1), 299-312.
Sato, T., Vries, R. G., Snippert, H. J., Van De Wetering, M., Barker, N., Stange, D. E., ... & Clevers, H. (2009). Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche. Nature, 459(7244), 262.
Van de Wetering, M., Francies, H. E., Francis, J. M., Bounova, G., Iorio, F., Pronk, A., ... & Clevers, H. (2015). Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell, 161(4), 933-945.
Members
| Hans Clevers Advisor/Guest Researcher | Amanda Andersson-Rolf Postdoc fellow | Antonella Dost Postdoc |
| Chunyang Mu PhD Student | Daisong Wang Postdoc | Daniel Krueger Post Doc |
| Dirk Jan Mastebroek PhD student | Hanxiao Chen Postdoc | Harry Begthel Lab assistant |
| Johan (Hendrikus) van Es Group leader | Joost Wijnakker PhD student | Katarina Balázová PhD student |
| Laura Zeinstra Technician | Lisanne van Rooijen Technician | Lulu Huang Phd student |
| Martina Celotti Phd student | Matthijs Abendroth Technician | Patricia Hamersveld Technician |
| Robin Schreurs PhD Student | Sam Willemsen PhD student | Sangho Lim Post Doc |
| Sarina Shabso Post Doc | Stieneke van den Brink | Theodore Grenier Post Doc |
| Veerle Geurts Technician | Xuan Zheng Postdoc | Yichao Zheng Postdoc |